DEPARTMENT OF NEUROSURGERY
DELL CHILDREN'S MEDICAL CENTER
Kumar Lab UT AUSTIN · DELL MED Menu

PEDIATRIC NEURO-ONCOLOGY · UT AUSTIN

Replacing the brain’s immune cells to treat childhood brain tumors.

The Kumar Lab studies how brain tumors reshape their immune environment and engineers microglia replacement strategies to turn the brain’s resident immune cells into a platform for therapy.

Dr. Kumar and the surgical team during a pediatric neurosurgical procedure at Dell Children's Medical Center
40+
peer-reviewed articles published by Dr. Kumar, career to date
35+
presentations by Dr. Kumar at national and international meetings
10
scientists, clinicians and students currently in the lab

OUR FOCUS

From mechanism to the operating room

Four connected lines of work, brought together by clinicians and scientists who care for these patients and study their disease.

MECHANISM

Tumor–immune interactions

How tumor-derived signals reprogram microglia and other immune cells into states that support tumor growth.

THERAPY

Microglia replacement

Repopulating the brain with engineered microglia and using them as a therapeutic platform against tumor progression.

OUTCOMES

Cognition & survivorship

How treatment shapes long-term cognitive outcomes in children with brain tumors — and how to better support patients and families.

TRANSLATION

From patients to the laboratory and back

Preclinical models, a pediatric neurosurgical tissue biobank, and an active surgical practice at Dell Children’s Medical Center.


OUR MISSION

Brain tumor research and cellular therapeutics

The Kumar Lab is dedicated to advancing the field of pediatric neurosurgery, with a primary focus on brain tumor research and cellular therapeutics.

By investigating the complex interactions between tumor cells and the brain's immune environment, the lab aims to unravel the mechanisms driving tumor growth and progression. Utilizing state-of-the-art techniques such as flow cytometry, advanced microscopy, next-generation sequencing, and stem cell biology, the team pioneers innovative microglia replacement protocols to deliver therapeutics against tumor progression.

Committed to bridging the gap between research and clinical application, the Kumar Lab strives to translate groundbreaking discoveries into transformative treatments that enhance outcomes for patients with brain tumors.

Dr. Kumar operating under the microscope at Dell Children's Medical Center
In the operating room at Dell Children’s Medical Center—where our research questions begin and where the answers ultimately matter.

RESEARCH PROGRAM

Four connected lines of work

MECHANISM

Tumor–immune interactions

How do glioma cells reshape the immune environment around them? We study how tumor-derived signals reprogram microglia and other immune cells into states that support tumor growth, and map these interactions across the pediatric glioma microenvironment.

THERAPY

Microglia replacement

Building on the first proof of concept for CNS-wide microglia replacement, we are developing strategies to repopulate the brain with engineered microglia and use them as a therapeutic platform against tumor progression.

OUTCOMES

Cognition & survivorship

Survival is only one measure of success. We study how surgery, radiation, and other treatments shape long-term cognitive outcomes in children with brain tumors, and develop approaches to better support patients and families throughout treatment and survivorship.

TRANSLATION

From patients to the laboratory and back

Preclinical models of pediatric glioma, a pediatric neurosurgical tissue biobank, and an active surgical practice at Dell Children’s Medical Center connect clinical questions, patient-derived tissue, and experimental therapeutics. This keeps the work anchored to the children and families it is meant to help.


IN THE LAB

Methods

Single-cell & spatial transcriptomics Flow cytometry & immune profiling High-resolution imaging Microglia & myeloid cell engineering Microglia replacement & CNS repopulation Extracellular vesicle biology Tumor–microenvironment modeling Preclinical pediatric glioma models Pediatric neurosurgical tissue biobanking

OUR TEAM

Physician-scientists, researchers, and trainees

A multidisciplinary team bringing different perspectives to the same problem: improving how we understand and treat childhood brain tumors.

The Kumar Lab team at the Health Discovery Building, Dell Medical School
Kevin K. Kumar, MD, PhD, at the University of Texas Tower

PRINCIPAL INVESTIGATOR

Kevin K. Kumar, MD, PhD

  • Assistant Professor of Neurosurgery, Dell Medical School
  • Surgical Director of Neuro-Oncology, Dell Children's Medical Center
  • Pediatric Neurosurgeon, UT Health Austin Pediatric Neurosciences

Dr. Kumar specializes in the treatment of pediatric brain and spine tumors, vascular malformations, developmental anomalies and epilepsy. He practices as a pediatric neurosurgeon at Dell Children's Medical Center, and is board-eligible by the American Board of Neurological Surgery and the American Board of Pediatric Neurological Surgery.

He completed his undergraduate education at Cornell University in 2009, graduating cum laude with distinction in research, then received his M.D. (2016) and Ph.D. (2014) from Vanderbilt University's NIH-funded Medical Scientist Training Program as a member of Aaron Bowman's laboratory in the Vanderbilt Brain Institute. His dissertation investigated neuronal manganese regulation in Parkinson's and Huntington's disease using high-throughput screening, induced pluripotent stem cells and chemical biology.

Full biography

Dr. Kumar completed his neurosurgery residency at Stanford University from 2016–2023, serving as chief resident in 2022–2023. At Stanford he completed a two-year NIH NINDS R25-funded research fellowship in Marius Wernig's laboratory at the Stanford Institute for Stem Cell Biology and Regenerative Medicine, developing a platform to replace microglia in the brain as a novel therapy for neurodevelopmental disorders — work that produced the first proof of concept for the technology in a mouse model of a lysosomal storage disorder. Alongside that basic science he published on neuromodulation, epilepsy, pediatric trauma, spine and vascular pathologies. He completed his pediatric neurosurgery fellowship at Lucile Packard Children's Hospital at Stanford in 2023–2024.

On joining the faculty at UT Austin, he launched this laboratory to develop cellular-based therapeutics for pediatric neurological disorders. He has published more than 40 peer-reviewed articles and delivered over 35 presentations at national and international meetings.

His training was recognized with the Donald O. Quest Medical Student Basic Science Award (AANS), the Elaine Sanders-Bush Neuroscience Research Prize, the John G. Coniglio Prize in Biochemistry, the Edwin Boldrey Young Investigator Award, the Philip L. Gildenberg Resident Award (AANS), and Stanford's Resident Basic Science Research Award. As faculty he was selected as an NIH K12 Scholar by NCATS, a Texas Biodesign Fellow, and a participant in the Neurosurgeon Research Career Development Program's Academy Emerging Investigators Program. He received the 2025 Cain Collaborative Research Pilot Grant and the Dell Medical School Department of Pediatrics Research Grant, and was named the 2026 Medicine and Healthcare winner at the Austin Under 40 Awards.

THE LAB

KS
Keisaku Sato, PhD
Staff Scientist
keisaku.sato@austin.utexas.edu
Read bio

Dr. Sato obtained his bachelor's degree in Japan and completed his Ph.D. in New Zealand. He arrived in the United States for postdoctoral training in 2011 to study hepatology and was promoted to Assistant Research Professor in 2019 at Indiana University School of Medicine. He joined the Kumar Lab in 2025 to study pediatric brain tumors. His research spans the liver–brain axis, cellular heterogeneity in the tumor microenvironment, and microglia replacement therapies for pediatric glioma, with extensive laboratory experience and strong expertise in bioinformatics and computation, including scRNA-seq and deconvolution analysis. His computational studies demonstrated that cell populations in liver tissue are altered by cell type and phenotype during chronic liver injury. His goal is to establish novel diagnostic and treatment strategies for human disease.

IM
Isabel Moreno, BS
PhD Student, Neuroscience
Interdisciplinary Neuroscience Program
isabel.moreno@utexas.edu
Read bio

Isabel graduated from Texas A&M University in 2025 as an Undergraduate Research Scholar with a B.S. in Molecular and Cellular Neuroscience and a minor in Dance Performance. She began research in the Grau lab at Texas A&M, studying spinal cord injury and pain; her undergraduate thesis explored the impact of norepinephrine on locomotor recovery after spinal cord injury. She is a first-year PhD student in the Interdisciplinary Neuroscience Program at UT Austin, and her dissertation work in the Kumar Lab centers on developing and optimizing novel therapeutic strategies for pediatric brain tumors.

CB
Cayley Brock, BSA
Research Assistant
cb54883@my.utexas.edu
Read bio

Cayley graduated from UT Austin in May 2026 with a Bachelor of Science and Arts in Molecular, Cell, and Developmental Biology, with a minor in Business and a certificate in Pre-Health Professions. She graduated with High Honors and Special Departmental Honors from the Department of Molecular Biosciences, and with Distinction in Research. Her honors thesis, completed in the Kumar Lab, was entitled "Glioma cells activate microglia into a pro-inflammatory and pro-tumoral phenotype." She was awarded the 2025 College of Natural Sciences Summer Experiential Learning Fellowship, the 2025–26 UT Undergraduate Research Fellowship, and the UT Undergraduate Research Travel Grant. She now studies the glioma tumor microenvironment full time while applying to MD/PhD programs.

CP
Curtis Pattillo, BS
Medical Student (MS3)
Dell Medical School
curtis.pattillo@utexas.edu
Read bio

Curtis earned his B.S. in molecular biology at Brigham Young University. Before graduating he served a two-year church mission to Melbourne, Australia, and studied Vietnamese language and culture during his service. During his undergraduate education he worked in the BYU Autism Behavior lab investigating parent–child relationships in families with children affected by neurodevelopmental disabilities. He was awarded the 2025 Department of Pediatrics Research Grant. His research interests include clinical outcomes of patients undergoing treatment for brain tumors. In his free time he enjoys running, biking, and spending time with his wife and son.

CA
Cheyenne Ahamed, BS
Medical Student (MS3)
Dell Medical School
cheyenne.ahamed@austin.utexas.edu
Read bio

Cheyenne received her B.S. in Biomedical Engineering with a concentration in Cellular and Biomolecular Engineering and a Pre-Health Professions certificate from UT Austin in May 2023. As an undergraduate she conducted sono-optogenetic research with applications to Parkinson's disease in the Wang Lab at UT Austin. In her gap year she worked as a research assistant in the Dunsmoor Lab at Dell Medical School, conducting behavioral and fMRI studies of how emotion shapes memory and learning, particularly in relation to PTSD. She is now an MS3 at Dell Medical School and is interested in novel therapeutics for neurodegenerative disorders in pediatric populations.

PM
Pierrick "Rick" Millet, MD
Biobank Senior Research Program Coordinator
pierrick.millet@austin.utexas.edu
Read bio

Pierrick "Rick" Millet was born in France and spent several years in Lodz, Poland, where he obtained his medical doctorate. He previously earned a Bachelor's in Biology at Northeastern University in Boston. He has since worked for AstraZeneca as an external consultant and applied his knowledge of regulatory affairs as a research coordinator at Texas State University. He currently manages the Neurosurgery Department's biobank and is interested in gene therapy for stroke research.

EB
Emma Bangen
Undergraduate Researcher
Neuroscience & Plan II Honors, '28
eab5338@my.utexas.edu
Read bio

Emma is a junior at UT Austin pursuing dual degrees in Neuroscience and Plan II Honors, with a certificate in Patients, Practitioners, and Cultures of Care. Her involvement in research began with the Freshman Research Initiative's Vertebrate Interactome Mapping lab, where she focused on cancer biology. She was awarded the 2026–27 UT Undergraduate Research Fellowship for her work on microglia replacement as a potential therapeutic strategy in mouse models of pediatric glioma. After graduation she plans to pursue MD/PhD training with a focus on neurosurgery.

BH
Bella Hu
Undergraduate Researcher
Biology, '27
isabellahu@utexas.edu
Read bio

Bella is a senior at UT Austin pursuing a degree in Biology with a concentration in Organismal Biology & Physiology, a minor in Health Communications, and a pre-health professions certificate. Her involvement in research began in the Freshman Research Initiative's Biodiversity Discovery stream, where she gained computational and laboratory background. She is also involved in Alpha Epsilon Delta, a pre-health professions honors society. Bella was awarded the 2025–26 UT Undergraduate Research Fellowship for her work on the impact of sleep patterns on cognitive recovery in pediatric brain tumor patients. She plans to attend medical school with a focus in pediatrics.

AA
Ananya Arora
Undergraduate Researcher
Biomedical Engineering Honors, '28
ananyaarora@utexas.edu
Read bio

Ananya is a junior at UT Austin pursuing a degree in Biomedical Engineering Honors with a minor in Business and a certificate in Humanitarian Engineering. Her involvement in research began in the Nanobiosensors and Molecular Tracking Lab, where she worked on nanosensing and a universal biosensor for low-cost diagnostics. She is also involved with the Health Leadership Apprentice Program at Dell Medical School. After graduation she plans to apply to MD or MD/PhD programs, with interests in pediatrics, oncology, and translational neuroscience.

SELECTED PUBLICATIONS

Publications

Selected publications spanning pediatric neurosurgery, brain tumor biology, and translational neuroscience—from current work at UT Austin to earlier work at Stanford and Vanderbilt.

The complete bibliography is maintained at NCBI. Search the list below by title, author or journal, or filter it by year.

Dr. Kumar and a colleague operating under the microscope at Dell Children's Medical Center
Extracranial-intracranial (EC-IC) bypass, Dell Children's Medical Center.
  • 2026

    Posterior Approach for Microsurgical Resection of a Ventrolateral Cervical Ganglioneuroma: an Illustrative Case and Technical Report

    Kohli V, Castano VG, Coffey AM, Green ST, Patel B, Rizk EB, Kumar KK

    Journal of Visualized Experiments2026 · (234):e71914doi 10.3791/71914
    Read paper
  • 2026

    Developing a core outcome set for the NeuroPoint Alliance Quality Outcomes Database Pediatric Tumor Surgery Registry: a modified Delphi study

    Hersh DS, Asher AL, Bydon M, Delawan M, Pollack IF, Hauptman JS, Thompson EM, Dewan MC, Akbari SHA, Balsara K, Barnett RR, Bercu MM, Braga BP, Couture DE, DeCuypere M, Garcia D, Gernsback J, Hamilton KM, Harter DH, Katz J, Kumar KK, Li D, Marupudi NI, Prolo LM, Ritter AM, Sadegh C, Salehi A, Sandoval-Garcia C, Tailor JK, Tanaka T, Tu A, Wait SD, Winer JL, Souweidane MM

    Journal of Neuro-Oncology2026 · 177(3):147PMID 42118351
    Read paper
  • 2026

    Metabolic Landscape and Emerging Therapeutic Potential in Pediatric and Adult Gliomas

    Brock CS, Nguyen L, Pattillo C, Ahamed CJ, Sato K, Kumar KK

    International Journal of Molecular Sciences2026 · 27(6):2720
    Read paper
  • 2025

    Targeting the Tumor Microenvironment in Pediatric Gliomas: Advances and Future Directions in Immunotherapy

    Ahamed C, Nguyen L, Brock CS, Farzamnia A, Millet P, Sato K, Kumar KK

    Neuro-Oncology Advances2025 · vdaf193PMID 41030523
    Read paper
  • 2025

    Intracranial neuromodulation for pediatric drug-resistant epilepsy: early institutional experience

    Uchitel J, Lui A, Knowles J, Parker JJ, Phillips HW, Halpern CH, Grant GA, Buch VP, Hyslop A, Kumar KK

    Frontiers in Surgery2025 · 12:1569360PMID 40264742
    Read paper
  • 2024

    Exploring cellular mechanisms and restorative cell-based therapeutics for epilepsy

    Kim LH, Haider MA, Kumar KK, Buch VP

    touchREVIEWS in Neurology2024 · 20(1):1–3
    Read paper
  • 2022

    Treatment of a genetic brain disease by CNS-wide microglia replacement

    Shibuya Y, Kumar KK, Mader MM, Yoo Y, Ayala LA, Zhou M, Mohr MA, Neumayer G, Kumar I, Yamamoto R, Marcoux P, Liou B, Bennett FC, Nakauchi H, Sun Y, Chen X, Heppner FL, Wyss-Coray T, Südhof TC, Wernig M

    Science Translational Medicine2022 · 14(636):eabl9945PMC9618306
    Read paper
  • 2022

    Management of Severe Traumatic Brain Injury in Pediatric Patients

    Lui A, Kumar KK, Grant GA

    Frontiers in Toxicology2022 · 4:910972PMID 35812167
    Read paper
  • 2019

    Comparative effectiveness of neuroablation and deep brain stimulation for treatment-resistant obsessive-compulsive disorder: a meta-analytic study

    Kumar KK, Appelboom G, Lamsam L, Caplan AL, Williams NR, Bhati MT, Stein SC, Halpern CH

    Journal of Neurology, Neurosurgery & Psychiatry2019 · 90(4):469–473PMID 30679237
    Read paper
  • 2019

    MR-Guided Focused Ultrasound Versus Radiofrequency Capsulotomy for Treatment-Refractory Obsessive-Compulsive Disorder: A Cost-Effectiveness Threshold Analysis

    Kumar KK, Bhati MT, Ravikumar VK, Ghanouni P, Stein SC, Halpern CH

    Frontiers in Neuroscience2019 · 13:66PMID 30792625
    Read paper
  • 2015

    Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status

    Kumar KK, Goodwin CR, Uhouse MA, Bornhorst J, Schwerdtle T, Aschner M, McLean JA, Bowman AB

    Metallomics2015 · 7(2):363–370PMID 25599126
    Read paper
  • 2014

    Cellular manganese content is developmentally regulated in human dopaminergic neurons

    Kumar KK, Lowe EW Jr, Aboud AA, Neely MD, Redha R, Bauer JA, Odak M, Weaver CD, Meiler J, Aschner M, Bowman AB

    Scientific Reports2014 · 4:6801PMID 25348053
    Read paper
  • 2012

    The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk

    Kumar KK, Aboud AA, Bowman AB

    NeuroToxicology2012 · 33(3):518–529
    Read paper
Complete bibliography on NCBI

MEDIA

News & coverage

Austin Under 40 Awards 2026 — Medicine and Healthcare winner, Kevin K. Kumar, MD, PhD
AUSTIN UNDER 40 AWARDS · MAY 2026

Austin Under 40 Awards recognizes Dr. Kumar

YMBL's Austin Under 40 Awards recognize emerging leaders across Austin for professional excellence and community impact while supporting Austin Sunshine Camps. Dr. Kumar was selected from more than 800 nominees as a 2026 honoree for his work as a pediatric neurosurgeon-scientist at Dell Medical School and Dell Children's, where he is building translational programs to advance care and new therapies for children with brain tumors.

Read more ↗

JOIN US

Opportunities

The Kumar Lab team in the laboratory, Health Discovery Building

The Kumar Lab is not conducting broad recruitment at this time — but we welcome inquiries from exceptional candidates whose interests align closely with our work.

We selectively consider highly qualified individuals at the staff scientist, postdoctoral, graduate, medical student, and undergraduate levels. Candidates with a strong record of academic achievement, technical expertise, and a clear commitment to pediatric brain tumor research may be considered for future opportunities.

If you believe your background aligns with the mission of the Kumar Lab, you are welcome to contact us to discuss whether a potential fit exists.

Areas of alignment

Neuro-oncology Microglia biology Cellular therapeutics
A student at work on the bench in the Kumar Lab Kumar Lab members at the Department of Neurosurgery resident research presentations